Prof. Giorgio Sartor

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HOME Anthropology Biochemistry of marine organisms Biomolecules ENZYMES Membranes Proteins Biochemistry of pollutants Energy Lipids Metabolism Signal transduction Enzyme kinetics Molecular motors Hydrolases Redox enzymes Enzymology ATPases Acethylcholinesterase Carbonic anhydrase Mechanisms Bacterial Flagellum Deacethylases Desaturase Dynein Glycosidases Dioxygenases Kinesin Lipases MONOOXYGENASES - CYP450 Microtubules Proteases Myosin Urease Applications of Stereospecifically-Labeled Fatty Acids in Oxygenase and Desaturase Biochemistry Biochemical Diversity of 2-Oxoglutarate-Dependent Oxygenases Biotransformations using prokaryotic P450 monooxygenases Complex reactions catalyzed by cytochrome P450 enzymes Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis COX-2 Inhibitory Effects of Naturally Occurring and Modified Fatty Acids Current directions for COX-2 inhibition in breast cancer Cytochrome P450 1A, 1B, and 1C mRNA induction patterns in three-spined stickleback exposed to a transient and a persistent inducer Cytochrome P450 Alkane Hydroxylases of the CYP153 Family Are Common in Alkane-Degrading Eubacteria Lacking Integral Membrane Alkane Hydroxylases Cytochrome P450 monooxygenase from Clostridium acetobutylicum: A new a-fatty acid hydroxylase Cytochrome P450 systems—biological variations of electron transport chains Cytochrome P450-redox partner fusion enzymes Cytochrome P450: major player in reperfusion injury Induction of eytochrome P4501A1: a model for analyzing mammalian gene transcription Cytochromes P450 as versatile biocatalysts Differential behavior of the sub-sites of cytochrome 450 active site in binding of substrates, and products(implications for coupling/uncoupling) DIRECT EVIDENCE FOR BIOSYNTHETIC RELATIONSHIPS AMONG HYDROCARBONS, SECONDARY ALCOHOLS AND KETONES IN BRASSICA OLERACEA Evidence for Protein Radical-Mediated Nuclear Tunneling in Fatty Acid alpha-Oxygenase Fatty acid oxygenase activity of human hair roots Fatty acid desaturation: variations on an oxidative theme Fatty acid transduction of nitric oxide signaling: Nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression Fatty Aldehyde and Fatty Alcohol Metabolism: Review and Importance for Epidermal Structure and Function Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes HYDROXYLATION OF 9-HYDROXYSTEARATE BY A SOLUBLE CYTOCHROME P-450-DEPENDENT FATTY ACID HYDROXYLASE FROM BACILLUS MEGATERIUM HYDROXYSTEARATES AS INHIBITORS OF PALMITATE HYDROXYLATION CATALYZED BY THE CYTOCHROME P-450 MONOOXYGENASE FROM BACILLUS MEGATERIUM Hydroxystearic Acids and the Biosynthesis of Unsaturated Fatty Acids In-crystal reaction cycle of a toluene-bound diiron hydroxylase Induction of cytochrome P4501A1 Lipid peroxidation: Mechanisms, inhibition, and biological effects Lipid peroxides induce expression of catalase in cultured vascular cells Lipoxygenases – Structure and reaction mechanism Lipoxygenases: Occurrence, Functions, Catalysis, and Acquisition of Substrate Mechanisms that regulate production of reactive oxygen species by cytochrome P450 Multiple mechanisms and multiple oxidants in P450-catalyzed hydroxylations Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms Metabolism of Hydroxy Fatty Acids -VI. Structure of Hydroxy Acids and the Degradation by Escherichia coli K-12 Mixed regiospecificity compromises alkene synthesis by a cytochrome P450 peroxygenase from Methylobacterium populi On the General Mechanism of Selective Induction of Cytochrome P450 Enzymes by Chemicals: Some Theoretical Considerations Oxidative Stress, Toxicology, and Pharmacology of Cyp2E1 Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors Polymorphisms of Xenobiotic-Metabolizing Enzymes and Susceptibility to Cancer Production of Eicosanoids and Other Oxylipins by Pathogenic Eukaryotic Microbes Properties of cytochrome P450 isoenzymes and their substrates Part 2: properties of cytochrome P450 substrates Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix Protein Radicals in Enzyme Catalysis Properties of cytochrome P450 isoenzymes and their substrates Part 1: active site characteristics Subcellular Localization of Membrane-Bound Aryl-Hydrocarbon Hydroxylase and NAD(P)H-Dependent Reductase Activities in Mouse Liver Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production Terminal Olefin (1-Alkene) Biosynthesis by a Novel P450 Fatty Acid Decarboxylase from Jeotgalicoccus Species The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution The great diversity of reactions catalyzed by cytochromes P450 The ins and outs of cytochrome P450s Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin Unraveling the pathway of lipid oxidation in the young pig: Assessment of hepatic β-oxidation and characterization of carnitine palmitoyltransferase I (CPT I) What common structural features and variations of mammalian P450s are known to date? 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